Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies

Epilepsy is one of the most common neurological disorders affecting people all ages representing a significant social and public health burden. Current therapeutic options for epilepsy are not effective in proportion patients suggesting need identifying novel targets development more therapeutics. There growing evidence from animal human studies role impaired brain energy metabolism mitochondrial dysfunction epilepsy. Candidate compounds with potential to target energetics have promising future management other related disorders. Creatine naturally occurring organic compound that serves as an buffer shuttle tissues, such skeletal muscle, exhibit dynamic requirements. In this review, applications creatine supplements conditions which central component its pathology will be discussed. Currently, limited mainly preclinical suggest anticonvulsant properties creatine; however, exact mechanism remain elucidated. Future work should involve larger clinical trials used add-on therapy, followed by large monotherapy.